Guide To Florida Keys: Resident’s Essential Tips

Last Update April 8, 2026

You are about to embark on a journey through the most beautiful tropical islands in the world. This guide to the Florida Keys is a log of our experiences as Florida residents who have spent over 30 years experiencing the spell of these legendary keys.

We start by answering the question of what is the difference between a key and an island?

The main difference between a key and an island comes down to how they were formed. A “key” (from the Spanish cayo) is a low-lying island, typically made of coral or sand, like the Florida Keys.

In contrast, an “island” can be any landmass surrounded by water, often formed by a variety of geological processes such as volcanic activity, or erosion. 

So, all keys are islands, but not all islands are keys.

Why Do You Need a Guide to Florida Keys

Very simply stated, there are hundreds of keys in the Florida Keys. Granted, not all are inhabited or easily accessible, but they are part of this island chain that starts just south of Miami, some 120 miles southwest.

You can find our research on all the Florida Keys and all their known names, but we will focus on what visitors want to see most. The islands most visited are the 42 Keys connected by bridges. 

All of the best things to do in the Florida Keys are on these connected islands or accessible by boat from their shores.

Another question we frequently get is, how much time should we spend in the Florida Keys? Without some guidance, you could spend weeks and not see all the highlights.

How to Get Around the Florida Keys

For the most part, traveling the Keys is easy. Depending on how you get to the Florida Keys, much of your travel will be on US Route 1, better known as the Overseas Highway.

The Overseas Highway is over 100 miles of road with a myriad of things to do and see along the way. Fortunately, the State of Florida has positioned mile markers along the way to make finding attractions in the Keys relatively easy.

In addition, we have documented over 150 mile markers and locations of places in the Florida Keys. You can find everything you need to find in this easy guide. For locating the major islands, you can use our Florida Keys Mile Marker Map as you travel.

Popular Florida Keys Destinations

Five islands represent the vast majority of all Florida Keys travel. The five Islands are:

• • Key Largo
  • Islamorada
  • Marathon
  • Big Pine Key
  • Key West

Each of these popular destinations in the Florida Keys is outlined below.

Key Largo

Key Largo, the northernmost island in the Florida Keys, is known as the “Diving Capital of the World.” It’s home to John Pennekamp Coral Reef State Park, the first undersea park in the U.S., where visitors can snorkel or scuba dive among vibrant coral reefs, sea turtles, and tropical fish. The crystal-clear waters of the adjacent Florida Keys National Marine Sanctuary make this a bucket-list destination for underwater explorers.

In addition to its marine life, Key Largo is also recognized for its laid-back island vibe and natural beauty. Mangrove-lined shorelines, kayak trails, and eco-tours offer visitors a chance to explore the unique coastal ecosystems. Bird watchers, boaters, and anglers also find paradise here, with calm backcountry waters and open ocean access.

Key Largo has also made a name for itself in film and pop culture. The island inspired the classic 1948 film Key Largo, starring Humphrey Bogart and Lauren Bacall, and you can even ride the historic African Queen steamboat from the movie. With its mix of adventure, nature, and nostalgia, Key Largo is a favorite first stop for anyone heading down the Overseas Highway.

Islamorada

Islamorada, often called the “Sportfishing Capital of the World,” is famous for its incredible fishing opportunities both offshore and in the backcountry waters of Florida Bay. Anglers flock here to catch tarpon, sailfish, mahi-mahi, and more, with plenty of charter boats and experienced guides ready to take visitors out. The village hosts several renowned fishing tournaments each year, drawing serious competitors and casual enthusiasts alike.

Beyond fishing, Islamorada is known for its laid-back, artsy vibe and stunning waterfront views. The area is dotted with beachside bars, seafood restaurants, and galleries showcasing local art. Places like the Morada Way Arts District bring in travelers looking to relax, shop, and soak in a more low-key island culture compared to busier parts of the Keys.

Islamorada is also home to several family-friendly attractions, like our favorite, the Theater of the Sea, where guests can swim with dolphins or watch marine animal shows. Nature lovers enjoy kayaking through mangroves or visiting Windley Key Fossil Reef Geological State Park. With its mix of outdoor fun, local charm, and spectacular sunsets, Islamorada offers something for just about everyone.

Marathon

Marathon, located in the heart of the Florida Keys, is known for being a family-friendly destination with a strong maritime and boating culture. It spans across several keys, including Vaca Key, and offers easy access to both the Atlantic Ocean and the Gulf of Mexico. Its central location makes it a popular base for boating, fishing, and snorkeling trips, especially for those heading out to nearby reefs and sandbars.

One of Marathon’s most iconic landmarks is the Seven Mile Bridge, one of the longest bridges in the U.S., connecting Marathon to the Lower Keys. Visitors can walk or bike a portion of the old bridge, now restored as a pedestrian path with sweeping ocean views. The bridge is especially stunning at sunrise and sunset, making it a favorite photo spot and a symbol of the Florida Keys road trip experience.

Marathon is also known for its dedication to marine life and environmental preservation. The Turtle Hospital, which rescues and rehabilitates injured sea turtles, is a must-visit attraction, as is the Dolphin Research Center on nearby Grassy Key. With its mix of natural beauty, educational experiences, and small-town charm, Marathon offers a laid-back but engaging island getaway.