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Key West Trip From Miami: 1 Day Ultimate Itinerary

There’s something undeniably magical about the Florida Keys and the turquoise waters, the salty breeze, and the laid-back island vibe that feels a world away from Miami’s bustling energy. 

But here’s the secret: you don’t need a long weekend getaway or an extended vacation to experience it.

A well-planned road trip to the Florida Keys from Miami can offer a perfect taste of the islands, with stunning ocean views, delicious seafood, and unforgettable stops along the iconic Overseas Highway (now known as Jimmy Buffett Memorial Highway in 2025).

Here is what you will find in this Guide to Key West from Miami by car:

  • Mile by mile guide that is easy to follow
  • Must see attractions along the way
  • Best places to eat while in the Keys
  • Ways to plan your trip from Miami to Key West

Whether you’re craving adventure, relaxation, or simply a change of scenery, this Florida Keys itinerary has you covered. There are many ways to get to Key West and the Florida Keys; we think a road trip is the best!

Overseas Highway from Miami to the Florida Keys
Get ready for an iconic drive over the Overseas Highway.

Your Guide to A Key West Trip From Miami

In this guide, we will share our tried-and-true roadmap for an epic trip through the Florida Keys, crafted from countless trips down US-1 we have made.

From sunrise departures and must-stop breakfast spots to sunset dinners with a view, you’ll discover how to make every moment count.

Our 8-step Florida Keys itinerary is ahead, so grab your sunglasses, cue up your favorite road trip playlist, and let’s hit the road – the Florida Keys are calling!

You will see notations in the article such as (MM95). In the Keys, addresses can be hard to find. However, the State of Florida uses green mile markers to locate attractions and at each mile. They go from MM106 in Key Largo to MM0 in Key West. Use the button for a detailed MM list here. Look for the mile markers as you travel.

  1. Early Start: Hit the Road on the Iconic Overseas Highway

The key to an unforgettable day trip to the Keys? An early start. Aim to hit the road by 6:00 or 7:00 AM to make the most of your adventure and avoid Miami’s notorious morning traffic.

Plus, there’s something special about cruising down US-1 with the sunrise painting the sky in shades of pink and gold—it sets the perfect tone for the day ahead.

day trip to the Keys from Miami railway marker
Railway marker that was used by Henry Flagler’s railway to Key West he attempted. It sits behind the Caribbean Club in Key Largo.

The Overseas Highway isn’t just a road; it’s an experience. Stretching over 113 miles and dotted with 42 bridges, this iconic route connects Miami to Key West, offering jaw-dropping views of turquoise waters and tiny islands along the way.

Roll down your windows, feel the salty breeze, and let the rhythm of island life take over.

Make sure you’ve packed your road trip essentials: sunglasses, sunscreen, a reusable water bottle, and, of course, a solid playlist featuring some Jimmy Buffett classics and breezy tropical tunes.

Don’t rush – part of the charm of this drive is soaking in the scenery. Whether it’s the sight of pelicans gliding over the water or the occasional glimpse of a dolphin, the Overseas Highway delivers postcard-worthy views at every turn.

Before long, you’ll reach Key Largo, the first stop in the Upper Keys, where breakfast and adventure await. But for now, enjoy the drive—it’s one of the best parts of the journey.

  1. First Stop: Breakfast in Key Largo

After about an hour of scenic driving, you’ll arrive in Key Largo, the northernmost and largest island in the Florida Keys. By now, you’ve likely worked up an appetite, and there’s no better way to kick off your Keys adventure than with a hearty breakfast at one of the island’s beloved local spots.

breakfast at Mrs. Mac's
There is nothing like a hearty breakfast at Mrs. Mac’s Kitchen in Key Largo.

For a classic Keys dining experience, head to Mrs. Mac’s Kitchen,(MM 99.3), a local institution famous for its quirky décor and mouthwatering breakfast dishes.

Go for the Captain’s Breakfast Platter or treat yourself to a slice of their legendary Key Lime Pie (yes, it’s acceptable to have pie for breakfast in the Keys!), you’re in for a delicious start.

Another fantastic option is the Key Largo Conch House,(MM 100.2), a cozy spot known for its fresh seafood omelets, Lobster Benedict, and rich Cuban coffee.

If you’re in the mood for a quick photo stop after breakfast, consider swinging by John Pennekamp Coral Reef State Park. Even if you’re not planning to snorkel or dive, the park offers a peaceful spot for a short stroll and a chance to take in the natural beauty of the mangroves and coastal waters.

With a full stomach and a dose of island charm, you’re ready to hit the road again. Next stop: Islamorada —the heart of the Keys and a seafood lover’s paradise.

  1. Mid-Morning: Snorkeling or Kayaking Adventure

No trip to the Florida Keys is complete without getting out on the water, and Key Largo and Tavernier are the perfect spots for a quick adventure before continuing south. Known as the Diving Capital of the World, this area offers crystal-clear waters, vibrant coral reefs, and an underwater world teeming with marine life.

If snorkeling is your thing, John Pennekamp Coral Reef State Park is the

Christ of the Abyss snorkeling at John Pennekamp
This statue of Christ stands underwater at John Pennekamp State Park for snorkelers.

go-to spot. You can join a guided snorkeling tour to explore the colorful reefs and even catch a glimpse of the famous Christ of the Abyss underwater statue. Tours typically last about 2–2.5 hours, so if you’re short on time, you can also explore the park’s short nature trails or relax by the shoreline.

For those who prefer to stay above the water, kayaking through the mangroves is an equally rewarding experience. Rent a kayak from one of the local outfitters, like Paddle the Florida Keys, and glide through serene tunnels of mangroves while spotting fish, crabs, and even the occasional manatee.

If you’re in a hurry or just want a quick taste of the Keys’ natural beauty, consider a short stop at Harry Harris Park in Tavernier. It’s a quieter spot with shallow, calm waters perfect for a quick dip or a scenic photo.

Once you’ve had your fill of ocean adventures, rinse off, grab a quick snack, and get ready for the next leg of your journey – Islamorada, where delicious seafood and coastal charm await.

Kayaking the Florida Keys
Kayaking is one of the fun adventures in the Florida Keys. We like Florida Bay best for exploring all the little islands.
  1. Lunch in Islamorada: Seafood Paradise

By midday, you’ll find yourself in Islamorada, often referred to as the Sportfishing Capital of the World.” But even if you’re not here to reel in the catch of the day, Islamorada is a must-stop for its laid-back vibe and some of the freshest seafood you’ll ever taste.

For a lunch with a view, head to Morada Bay Beach Café,(MM 81.6), a breezy outdoor spot right on the sand. Enjoy dishes like grilled mahi-mahi tacos, crab cakes, or a refreshing shrimp ceviche, all while taking in the turquoise water views. Another favorite is Lazy Days Restaurant, where you can dine with your toes in the sand and savor their famous Key Lime Butter Snapper—a true Florida Keys classic.

Snapper Dinner in the Florida Keys
You can get the freshest seafood in the world in the Florida Keys. A fresh snapper dinner can’t be beat!

No stop in Islamorada is complete without a visit to Robbie’s Marina, an iconic roadside attraction where you can feed the tarpon. No one plans a trip to the Keys from Miami without stopping at Robbie’s!

For just a few dollars, you can hand-feed these massive, silver-scaled fish as they leap out of the water—a uniquely Florida Keys experience you won’t forget. If you’re still feeling peckish, grab a quick snack or a frozen drink at Robbie’s Hungry Tarpon Restaurant before continuing your adventure.

Whether you linger over lunch or keep things quick, Islamorada offers a perfect mix of flavor, fun, and unforgettable views. With your appetite satisfied, it’s time to hit the road again and enjoy one of the most stunning stretches of the Overseas Highway.

  1. Afternoon: Scenic Drive and Photo Stops

As you leave Islamorada behind, the Overseas Highway transforms into one of the most breathtaking drives in the country. This stretch of road, flanked by endless blue skies and shimmering turquoise waters, offers plenty of opportunities to pull over, stretch your legs, and capture some postcard-perfect photos.

Bahia Honda State Park Beach
Bahia Honda State Park is a worthwhile stop on your Florida Keys road trip from Miami to relax and put your feet in the shallow ocean waters.

Your first must-see stop is really as you travel along the Seven Mile Bridge, one of the longest segmental bridges in the world.

If time allows, park at the Old Seven Mile Bridge access point and take a short walk along this historic structure. The views of the Atlantic Ocean on one side and the Gulf of Mexico on the other are absolutely stunning! Perfect for a quick photo op or simply soaking in the beauty of the Keys.

Next, swing by Bahia Honda State Park, a slice of paradise known for its powdery white sand beaches and clear waters. Even if you don’t have time for a swim, it’s worth a quick stop to admire the view from the Old Bahia Honda Bridge overlook.

It’s one of the best panoramic spots in the Keys and a favorite for photographers.

Boardwalk sat Anne's Beach
The boardwalk through the mangroves at Anne’s Beach leads to a small shallow beach.

As a side note, this is where we taught our children how to snorkel. Bahia Honda has shallow waters that make it easy to snorkel.

For a quieter stop, Anne’s Beach, (MM 73.4), in Lower Matecumbe Key is a hidden gem. Known for its shallow waters and scenic boardwalk, it’s the perfect spot for a peaceful walk or a few serene snapshots.

This part of the drive isn’t about rushing—it’s about savoring the journey. Take your time, pull over when something catches your eye, and let the beauty of the Keys wash over you. 

Up next on your road trip to the Florida Keys from Miami: a relaxing sunset stop and a delicious dinner with an unforgettable view. 

Key Deer in Big Pine Key
One stop you may consider is in Big Pine Key. Here is the only place in the world you will find Key Deer about the size of a large dog. They roam freely on the island.
  1. Key West 

Continuing your drive to Key West, the southernmost point in the continental United States, is well worth the extra mileage. Known for its colorful streets, quirky charm, and rich history, Key West offers a vibrant mix of culture, food, and stunning views—all packed into a small island.

Key West Southernmost Buoy
Everyone gets their picture taken at the Key West Southernmost Buoy.

Start your visit at the iconic Southernmost Point Buoy, a must-see photo spot just 90 miles from Cuba. From there, stroll down Duval Street, the island’s lively main thoroughfare, filled with quirky shops, lively bars, and charming cafes. If you have time for a quick historical stop, consider visiting the Ernest Hemingway Home and Museum, where you can meet the famous six-toed cats that still roam the property.

No visit to Key West is complete without experiencing the sunset celebration at Mallory Square. Street performers, musicians, and local artisans create an unforgettable atmosphere as the sun dips below the horizon in a fiery display of oranges and pinks. Grab a Key Lime Pie on a stick from a nearby vendor and savor the moment—it’s pure island magic.

If time feels tight, don’t stress. Key West is worth an overnight stay on another trip, and there’s still so much beauty to enjoy on your drive back. But if you do decide to make the trek, know that the reward is well worth the effort.

Seven Mile Bridge in Marathon
We consider the seven-mile bridge one of the wonders of the world. Note the remaining part of Flagler’s East Coast Railway next to the bridge.
  1. Sunset Stop: Dinner with a View

If you decide to skip Key West, don’t worry—you’re still in for an unforgettable sunset experience. As you make your way back north, plan to stop in Marathon or Islamorada for a relaxing dinner with front-row seats to one of the most stunning sunsets in Florida.

One of the best spots for this is Sunset Grille & Raw Bar in Marathon, located right at the foot of the Seven Mile Bridge. With an open-air dining area, tiki vibes, and panoramic ocean views, it’s the perfect spot to unwind after a day of exploring. Try the grilled mahi sandwich or the conch fritters, paired with a refreshing Key Lime Colada. As the sun dips below the horizon, you’ll understand why this spot is a favorite among locals and travelers alike.

If you prefer something a little more low-key, Lorelei Restaurant & Cabana Bar in Islamorada is another fantastic option. Known for its laid-back atmosphere and live music, this waterfront gem serves up delicious seafood dishes like blackened grouper tacos and their famous fish dip. Grab a cocktail, sink into one of their Adirondack chairs, and let the day wind down in true island style. If the timing is right the Lorelei would be our first choice for a great sunset over Florida Bay.

Wherever you choose to stop, take your time, breathe in the salty air, and savor the moment. The Florida Keys sunset isn’t just a view—it’s an experience, and it’s the perfect way to close out your adventure before hitting the road back to Miami.

Key Largo Sunset
There is nothing like the sunset over Florida Bay in Key Largo.
  1. Return Drive to Miami

As the sun sets and the sky fades into shades of twilight, it’s time to begin your drive back to Miami. The journey north along the Overseas Highway feels calmer at night, with the glow of the bridges reflecting on the water and the occasional twinkle of lights from waterfront homes and marinas.

To make the drive more enjoyable, have a playlist or podcast queued up—something light and fun to keep the vibes alive. If you’re feeling a bit sleepy, make a quick stop at a roadside café or gas station for a cup of Cuban coffee or a snack. Safety first: if you’re too tired, consider pulling over for a short break at a well-lit rest stop.

Expect to arrive back in Miami between 9:00 PM and midnight, depending on your dinner stop and how long you lingered at those scenic spots. While the drive can feel long, it’s also a peaceful way to reflect on the day’s adventures and let the beauty of the Keys linger a little longer in your mind. Even better is to find a hotel along the way and stay a little longer!

Your Key West from Miami Drive FAQs

How long does it take to drive from Miami to Key West?

The drive from Miami to Key West takes approximately 3.5 to 4 hours without stops, covering about 160 miles along the scenic Overseas Highway (U.S. Route 1).

Is the drive from Miami to Key West worth it?

Yes, the drive is considered one of the most scenic road trips in the U.S., featuring 42 bridges, ocean views, and charming Florida Keys towns along the way.

What is the best time of day to drive to Key West from Miami?

Morning is the best time to start the drive to avoid heavy traffic and to enjoy daylight views of the ocean and bridges.

What are the best stops between Miami and Key West?

Popular stops include Key Largo (John Pennekamp Coral Reef State Park), Islamorada (Robbie’s Marina), Marathon (Seven Mile Bridge), and Big Pine Key (National Key Deer Refuge).

Can you do a day trip to Key West from Miami by car?

Yes, it’s possible, but it makes for a long day. You’ll spend around 8 hours total driving, so an early start and late return are necessary.

Final Thoughts Trip to the Florida Keys from Miami

Mental Image of the Florida Keys
We asked one of the AI image models for a mental image of the Florida Keys. We thought this was pretty close!

A road trip to the Florida Keys from Miami is proof that you don’t need a week-long vacation to experience the magic of island life. From the scenic beauty of the Overseas Highway to fresh seafood lunches in Islamorada and golden sunsets over the water, every moment on this trip offers something special.

Whether you spent your day snorkeling in Key Largo, feeding tarpon at Robbie’s Marina, or simply soaking in the views from Seven Mile Bridge, the Florida Keys itinerary has a way of making even the shortest visit unforgettable.

So, next time you’re in Miami and craving a quick escape, remember: paradise is just a drive away. Pack your bags, cue up your road trip playlist, and let the adventure begin.

Have you taken a trip to the Florida Keys? Share your favorite stops and tips in the comments below! Don’t forget to follow Florida Travel Blog for more Florida travel inspiration.

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larry edger _ author Author’s Bio – Larry Edger – entrepreneur, business owner, consultant and primary author of Florida Travel Blog. After retiring from the fast-paced business world as President of a title insurance company, Mr. Edger went on to successfully invest and develop restaurants. In addition to restaurants and with a passion for travel and love of Florida, he began documenting fascinating destinations in what is now called Florida Travel Blog. Now Florida Travel Blog is one of the top go-to places on the internet for Florida travel information.

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